Structural alerts for permit categories
The structural alerts are classes of chemicals, functional groups or substructures that are linked to a particular endpoint. The absence of a structural alert does not mean that a chemical is non-hazardous or is not of concern for a particular end-point (unless defined by an exclusion/boundary).
Chemicals with a structural alert for corrosion are considered to have the potential to cause both skin and eye irritation.
The structural alerts have been compiled from references used internationally e.g. the US Environmental Protection Agency (US EPA) categories of concern and those commonly used by NICNAS. These alerts have been grouped as follows:
Structure contains only C, H, (O)
Structure contains only C, H, (O) and Halogen atoms
Structure contains only C, H, (O) and N atoms
Structure contains only C, H, (O), N and Halogen atoms
CNS and CNSHal
Structure contains only C, H, (O), N and S atoms or Structure
CS and CSHal
Structure contains only C, H, (O), and S atoms or Structure
CSi and CSiHal
Structure contains only C, H, (O), and Si atoms or Structure
Structure contains atoms other than C, H, N, O, S, Si and
In determining whether a chemical contains a structural alert, it may be necessary to consult more than one table, if different substructures of the chemical would be covered by different tables.
Boundaries and exclusions for the structural alerts have been included in the tables. Specific physicochemical exclusion rules for corrosion and skin/eye irritation have been included at the end of each table. These have been externally developed and validated. Those shown during validation to have limited predictive value or found to be not properly defined have not been included.
Last update 29 July 2018