Structural alerts for permit categories

Learn more about structural alerts for permits

The structural alerts are classes of chemicals, functional groups or substructures that are linked to a particular endpoint. The absence of a structural alert does not mean that a chemical is non-hazardous or is not of concern for a particular end-point (unless defined by an exclusion/boundary).

Chemicals with a structural alert for corrosion are considered to have the potential to cause both skin and eye irritation.

The structural alerts have been compiled from references used internationally e.g. the US Environmental Protection Agency (US EPA) categories of concern and those commonly used by NICNAS. These alerts have been grouped as follows:

C

Structure contains only C, H, (O)

Structural alert table 1

CHal

Structure contains only C, H, (O) and Halogen atoms

Structural alert table 2

CN

Structure contains only C, H, (O) and N atoms

Structural alert table 3

CNHal

Structure contains only C, H, (O), N and Halogen atoms

Structural alert table 4

CNS and CNSHal

Structure contains only C, H, (O), N and S atoms or Structure
contains only C, H, (O), N, S and Halogen atoms

Structural alert table 5

CS and CSHal

Structure contains only C, H, (O), and S atoms or Structure
contains only C, H, (O), S and Halogen atoms

Structural alert table 6

CSi and CSiHal

Structure contains only C, H, (O), and Si atoms or Structure
contains only C, H, (O), Si and Halogen atoms

Structural alert table 7

Other

Structure contains atoms other than C, H, N, O, S, Si and
Halogen atoms

Structural alert table 8

In determining whether a chemical contains a structural alert, it may be necessary to consult more than one table, if different substructures of the chemical would be covered by different tables.

Boundaries and exclusions for the structural alerts have been included in the tables. Specific physicochemical exclusion rules for corrosion and skin/eye irritation have been included at the end of each table. These have been externally developed and validated. Those shown during validation to have limited predictive value or found to be not properly defined have not been included.

Last update 29 July 2018