Indirect precusors of perfluoroalkane sulfonic acids (PFSA) (C5-C7): Human health tier II assessment

03 July 2015

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Chemicals in this assessment

Chemical Name in the Inventory CAS Number
2-Propenoic acid, 2-[ethyl[(tridecafluorohexyl)sulfonyl]amino]ethyl ester 1893-52-3
1-Hexanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-N-(2-hydroxyethyl)- 34455-03-3
1-Propanaminium, N-(2-hydroxyethyl)-N,N-dimethyl-3-[(3-sulfopropyl)[(tridecafluorohexyl)sulfonyl]amino]-, hydroxide, inner salt 38850-58-7
1-Propanaminium, N,N,N-trimethyl-3-[[(tridecafluorohexyl)sulfonyl]amino]-, chloride 52166-82-2
Poly(oxy-1,2-ethanediyl), .alpha.-[2-[ethyl[(tridecafluorohexyl)sulfonyl]amino]ethyl] 56372-23-7
2-Propenoic acid, 2-[ethyl[(pentadecafluoroheptyl)sulfonyl]amino]ethyl ester 59071-10-2
1-Propanaminium, N,N,N-trimethyl-3-[[(undecafluoropentyl)sulfonyl]amino]-, chloride 68957-55-1
1-Propanaminium, N,N,N-trimethyl-3-[[(undecafluoropentyl)sulfonyl]amino]-, iodide 68957-57-3
1-Propanaminium, N,N,N-trimethyl-3-[[(tridecafluorohexyl)sulfonyl]amino]-, iodide 68957-58-4
1-Pentanesulfonamide, N-[3-(dimethylamino)propyl]-1,1,2,2,3,3,4,4,5,5,5-undecafluoro-, monohydrochloride 68957-60-8
1-Hexanesulfonamide, N-[3-(dimethylamino)propyl]-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, monohydrochloride 68957-61-9
Poly(oxy-1,2-ethanediyl), .alpha.-[2-[ethyl[(pentadecafluoroheptyl)sulfonyl]amino]ethyl] 68958-60-1
Glycine, N-ethyl-N-[(undecafluoropentyl)sulfonyl]-, potassium salt 67584-52-5
Glycine, N-ethyl-N-[(tridecafluorohexyl)sulfonyl]-, potassium salt 67584-53-6
1-Propanaminium, N,N,N-trimethyl-3-[[(pentadecafluoroheptyl)sulfonyl]amino]-, iodide 67584-58-1
Glycine, N-ethyl-N-[(pentadecafluoroheptyl)sulfonyl]-, potassium salt 67584-62-7
1-Heptanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-[2-(phosphonooxy)ethyl]- 67923-61-9
1-Pentanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,5-undecafluoro-N-[2-(phosphonooxy)ethyl]- 67939-90-6
1-Heptanesulfonamide, N,N',N''-[phosphinylidynetris(oxy-2,1-ethanediyl)]tris[N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro- 67939-94-0
1-Heptanesulfonamide, N,N'-[phosphinicobis(oxy-2,1-ethanediyl)]bis[N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-, ammonium salt 67939-97-3
1-Heptanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-[2-(phosphonooxy)ethyl]-, diammonium salt 67939-98-4
1-Heptanesulfonamide, N-[3-(dimethylamino)propyl]-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-, monohydrochloride 67940-02-7
1-Hexanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-N-[2-(phosphonooxy)ethyl]- 67969-65-7
Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-[2-[ethyl[(tridecafluorohexyl)sulfonyl]amino]ethyl] 68259-38-1
Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-[2-[ethyl[(pentadecafluoroheptyl)sulfonyl]amino]ethyl] 68259-39-2
2-Propenoic acid, 2-[ethyl[(undecafluoropentyl)sulfonyl]amino]ethyl ester 68298-06-6
Poly(oxy-1,2-ethanediyl), .alpha.-[2-[ethyl[(undecafluoropentyl)sulfonyl]amino]ethyl] 68298-80-6
Poly(oxy-1,2-ethanediyl), .alpha.-[2-[ethyl[(pentadecafluoroheptyl)sulfonyl]amino]ethyl] 68298-81-7
Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-[2-[ethyl[(undecafluoropentyl)sulfonyl]amino]ethyl] 68310-17-8
Benzoic acid, 2,3,4,5-tetrachloro-6-[[[3-[[(pentadecafluoroheptyl)sulfonyl]oxy]phenyl]amino]carbonyl]-, monopotassium salt 68541-01-5
Benzoic acid, 2,3,4,5-tetrachloro-6-[[[3-[[(undecafluoropentyl)sulfonyl]oxy]phenyl]amino]carbonyl]-, monopotassium salt 68541-02-6
1-Pentanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,5-undecafluoro-N-(2-hydroxyethyl)- 68555-72-6
1-Heptanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-(2-hydroxyethyl)- 68555-73-7
1-Pentanesulfonamide, 1,1,2,2,3,3,4,4,5,5,5-undecafluoro-N-(2-hydroxyethyl)-N-methyl- 68555-74-8
1-Hexanesulfonamide, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-N-(2-hydroxyethyl)-N-methyl- 68555-75-9
1-Heptanesulfonamide, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N-(2-hydroxyethyl)-N-methyl- 68555-76-0
1-Propanaminium, N,N,N-trimethyl-3-[[(pentadecafluoroheptyl)sulfonyl]amino]-, chloride 68555-81-7
Benzoic acid, 2,3,4,5-tetrachloro-6-[[[3-[[(tridecafluorohexyl)sulfonyl]oxy]phenyl]amino]carbonyl]-, monopotassium salt 68815-72-5
Chromium, diaquatetrachloro[.mu.-[N-ethyl-N-[(pentadecafluoroheptyl)sulfonyl]glycinato-O1:O1']] 68891-97-4
Chromium, diaquatetrachloro[.mu.-[N-ethyl-N-[(tridecafluorohexyl)sulfonyl]glycinato-O1:O1']][2-propanol]di- 68891-98-5
Chromium, diaquatetrachloro[.mu.-[N-ethyl-N-[(undecafluoropentyl)sulfonyl]glycinato-O1:O1']][2-propanol]di- 68891-99-6
1-Propanesulfonic acid, 3-[[3-(dimethylamino)propyl][(tridecafluorohexyl)sulfonyl]amino]-2-hydroxy-, monosodium salt 73772-32-4
1-Propanaminium, N-(2-hydroxyethyl)-3-[(2-hydroxy-3-sulfopropyl)[(tridecafluorohexyl)sulfonyl]amino]-N,N-dimethyl-, hydroxide, monosodium salt 81190-38-7


This assessment was carried out by staff of the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) using the Inventory Multi-tiered Assessment and Prioritisation (IMAP) framework.

The IMAP framework addresses the human health and environmental impacts of previously unassessed industrial chemicals listed on the Australian Inventory of Chemical Substances (the Inventory).

The framework was developed with significant input from stakeholders and provides a more rapid, flexible and transparent approach for the assessment of chemicals listed on the Inventory.

Stage One of the implementation of this framework, which lasted four years from 1 July 2012, examined 3000 chemicals meeting characteristics identified by stakeholders as needing priority assessment. This included chemicals for which NICNAS already held exposure information, chemicals identified as a concern or for which regulatory action had been taken overseas, and chemicals detected in international studies analysing chemicals present in babies’ umbilical cord blood.

Stage Two of IMAP began in July 2016. We are continuing to assess chemicals on the Inventory, including chemicals identified as a concern for which action has been taken overseas and chemicals that can be rapidly identified and assessed by using Stage One information. We are also continuing to publish information for chemicals on the Inventory that pose a low risk to human health or the environment or both. This work provides efficiencies and enables us to identify higher risk chemicals requiring assessment.

The IMAP framework is a science and risk-based model designed to align the assessment effort with the human health and environmental impacts of chemicals. It has three tiers of assessment, with the assessment effort increasing with each tier. The Tier I assessment is a high throughput approach using tabulated electronic data. The Tier II assessment is an evaluation of risk on a substance-by-substance or chemical category-by-category basis. Tier III assessments are conducted to address specific concerns that could not be resolved during the Tier II assessment.

These assessments are carried out by staff employed by the Australian Government Department of Health and the Australian Government Department of the Environment and Energy. The human health and environment risk assessments are conducted and published separately, using information available at the time, and may be undertaken at different tiers.

This chemical or group of chemicals are being assessed at Tier II because the Tier I assessment indicated that it needed further investigation.

For more detail on this program please


NICNAS has made every effort to assure the quality of information available in this report. However, before relying on it for a specific purpose, users should obtain advice relevant to their particular circumstances. This report has been prepared by NICNAS using a range of sources, including information from databases maintained by third parties, which include data supplied by industry. NICNAS has not verified and cannot guarantee the correctness of all information obtained from those databases. Reproduction or further distribution of this information may be subject to copyright protection. Use of this information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. NICNAS does not take any responsibility whatsoever for any copyright or other infringements that may be caused by using this information.

Grouping Rationale

The chemicals in this group are both non-polymeric substances and side-chain fluorinated polymers containing 5–7 perfluorinated carbons linked to a sulfonic ester or sulfonamide group.

NICNAS has developed an action plan to assess and manage chemicals which might degrade to perfluorinated carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) or similar chemicals. The action plan can be found in Appendix G of the Handbook for notifiers on the NICNAS website (NICNASa). The primary assumption outlined in this plan is that chemicals with a perfluorinated chain terminated by a sulfonyl group will degrade to PFSAs of the same chain length. On this basis, the chemicals in this group have the potential to degrade into a range of environmentally persistent PFSA anions (namely perfluoropentane sulfonate, perfluorohexane sulfonate or perfluoroheptane sulfonate anions) and, therefore, are considered to be indirect precursors of PFSAs (C5–C7).

The degradation of PFSAs is very slow compared with their rate of formation from precursor degradation, and PFSAs will be the final degradant from all of these precursors. Therefore, the amount of the PFSAs in the environment (general or local) is expected to be higher than that of any of the individual precursors. Whilst fluorinated polymers generally do not present significant risks, direct exposure to the non-polymeric substances in this group could pose health risks. However, the available information indicates that any use of these non-polymers is in small volume and/or low concentrations in Australia (see Australian import, manufacture and use). Consequently, the most important health risk is expected to arise from secondary exposure to PFSAs through the environment. As such, the focus of this assessment is on the long-term effects of the chemicals due to the chemicals degrading to PFSAs (C5–C7). Acute and local effects have not been considered.

Direct precursors of PFSAs (C5–C7) have been assessed earlier in order to compare their toxicity profile with that of perfluorooctane sulfonic acid (PFOS) (NICNASb).


No specific Australian use, import, or manufacturing information has been identified. However, general information on the use of PFSAs has been reported. The most recent data collected by NICNAS indicate that PFSAs are predominantly used in Australia in mist suppressants for the metal plating industry and in fire fighting foams. Approximately 60 tonnes of fire fighting foams containing perfluoroalkyl sulfonates at concentrations up to 5 % were held in Australia in 2007. Other uses included carpet treatments, curatives, industrial coatings and printing inks (NICNAS, 2013).

In 2004, it was reported that 1.6 tonnes of PFSAs and related chemicals were imported into Australia. By 2007, the imported quantity of these chemicals had increased to 13.6 tonnes. It was reported that the majority of these imports were of chemicals based on the C4 homologue, perfluorobutanesulfonic acid (PFBS). The chemicals in this group are not manufactured in Australia (NICNAS, 2013).

It is noted that some of the chemicals in this group could be present in the environment due to historic use, due to release from articles or as breakdown products resulting from using other indirect precursor chemicals covered in this assessment.


Due to their unique chemical properties perfluorinated chemicals and their precursors have found use in a wide range of industrial applications. However, concerns regarding the persistence and bioaccumulation hazards of long-chain perfluoroalkyl sulfonates resulted in the largest manufacturer of these chemicals ceasing their production in 2002 (Buck, et al., 2011). This is expected to have significantly reduced global supply of C6 and C7 perfluoroalkyl sulfonate derivatives. It should be noted, however, that perfluorohexanesulfonyl fluoride (CAS No. 423-50-7) is a likely precursor for many of the chemicals in this group and this chemical was reportedly produced in the United States in 2008 (OECD, 2011). Current production volumes of C5 perfluoroalkyl sulfonate derivatives are unclear. A number of the chemicals in this group are pre-registered under the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) legislation, but none have been registered under the REACH legislation at the time of assessment.

Nevertheless, many perfluoroalkyl sulfonamides and their derivatives appear to be used in the production of other fluorochemical products, such as surfactant materials (Buck, et al., 2011). The N-alkyl perfluoroalkanesulfonamide acrylates, such as CAS Nos 59071-10-2, 1893-52-3 and 68298-06-6, are reported to be used as co-monomers in the synthesis of acrylic polymers that are used in surface protection applications (Buck, et al., 2011). In addition, use of the three perfluoroalkyl sulphonamide acetate salts in this group (CAS RNs 67584-52-5, 67584-53-6 and 67584-62-7) was reported in 2012 in Denmark (SPIN). Data available for the homologous C8 perfluoroalkyl sulphonamide acetate salt suggest these chemicals may have use in surface treatments, cleaning products and floor waxes (NICNASc).

Less information is available for the remaining chemicals in this group. However, it is noted that data for the homologous C8 chemicals suggest the perfluoroalkyl sulfonamide phosphate esters may be used in fabric paper treatments, paints, lacquers and varnishes, while the polyglycol derivatives may be used in surfactant preparations (NICNASc).

No evidence of the presence of these chemicals in consumer products was found in the available North American databases (Household Products Database and Personal Care Council), indicating that the chemicals are not likely to be widely available for domestic or cosmetic uses.


No known mandatory restrictions have been identified.

Measures taken to date to reduce the importation and use of PFSA compounds and their salts and precursors has largely been through NICNAS recommendations (published as alerts as part of NICNAS Factsheets) since 2002 and subsequent voluntary action by industry. The latest NICNAS alert Factsheet (published in 2008) recommended that PFOS- and related PFSA-based chemicals be restricted to only essential uses for which no suitable or less hazardous alternatives were available (NICNAS, 2013).


In the United States of America (USA), all the chemicals in this group are subject to a Significant New Use Rule (SNUR). These SNURs allow the continuation of a few limited, highly technical uses of these chemicals for which no alternatives are available, and which are characterised by very low volume, low exposure, and low releases. Any other uses of these chemicals required prior notice to, and review by, the US Environmental Protection Agency (EPA) (US EPA, 2002; US EPA, 2007). The EPA is currently proposing to modify this existing SNUR to make inapplicable the exemption for persons who import PFSA chemical substances as a component of carpets (US EPA, 2015).

In Canada, substances having perfluoroheptyl derivatives with the formula C7F15 as a structural element, except those derivatives with the formula C7F15 X, where X = F, Cl, Br are listed under Schedule 1 (the Toxic Substances List) of the Canadian Environmental Protection Act 1999 (Government of Canada, 1999).

In Europe, a proposal to ban the manufacture, use and placing on the market as substances on their own, as constituents of other substances, in a mixture or in articles is being considered for substances having linear or branched perfluoroheptyl derivatives with the formula C7F15 as a structural element, including its salts except those derivatives with the formula C7F15 X, where X= F, Cl, Br (ECHA, 2015).

Whilst perfluorooctane sulfonate (PFOS) is restricted in several countries, the chemicals in this group are not covered by these restrictions.

Existing Worker Health and Safety Controls

Hazard Classification

The chemicals are not listed on the Hazardous Substances Information System (HSIS) (Safe Work Australia).


No specific exposure standards are available for the chemicals in this group.


No specific exposure standards are available for the chemicals in this group.

Toxicological data for this group of chemicals are not available. Whilst direct exposure to fluorinated polymers generally does not present significant risks, direct exposure to the non-polymeric substances in this group could pose health risks. However, the available information indicates that any use of these non-polymers is in small volume and/or low concentrations in Australia. Therefore, the primary health risk for the chemicals in this group is expected to arise from secondary exposure to PFSAs (C5–C7) (see Grouping rationale). Both PFOS and perfluorohexanesulfonate (PFHxS) are well absorbed by the digestive tract and are mainly accumulated in the liver, followed by plasma, kidneys and lungs. Once absorbed, these perfluorinated chemicals (PFCs) are eliminated from the human body very slowly. Mean elimination half-lives of PFOS of up to 8.7 years have been reported in retired workers, with a lower values (5.4 years (arithmetic mean) and 4.8 years (geometric mean) reported in more recent sampling. The mean elimination half-life of PFHxS was 7–8 years (Sundstrom et al., 2012; NICNASb).

Biomonitoring studies have shown that exposure in the general population is widespread and that PFHxS and PFOS are the PFSAs commonly present in human serum (Calafat et al., 2006; Fromme et al., 2007; Kato et al., 2011). In pooled human sera from the Australian population, PFOS was the highest PFSA detected, with concentrations of 4.4–17.4 ng/mL. PFHxS levels ranged from 1.2–5.7 ng/mL (08/09) and 1.4–5.4 ng/mL (10/11). Median levels of PFHxS have not significantly changed from 2002 (Toms et al., 2014).

Perfluoroalkyl compounds have been found in human breast milk, but there are no studies that looked at whether a baby's health was affected by drinking this milk. Levels of perfluoroalkyls in breast milk are much lower than in the mother’s blood, indicating that these substances are not concentrated during milk production (ATSDR, 2009).

Where available, hazard data for PFHxS can be used to estimate hazards for this group's chemical degradation products that contain five or six perfluorinated carbons. In the absence of toxicological data, PFOS hazard information is used to estimate systemic hazards.

Critical Health Effects

The critical health effects for the chemicals in this group are considered to be long-term due to the degradation to PFSAs (C5–C7). Acute and local effects have not been considered.

Data available for the direct precursors of PFSA (C5–C7) (NICNASb) indicate that there is the potential for systemic long-term effects (hepatotoxicity) at low doses and possible carcinogenicity. The chemicals in this group with 6 perfluorinated carbon chains were not considered to be reproductive/developmental toxins at low dose levels. However, in the absence of information for the chemicals with >6 perfluorinated carbons, developmental effects similar to those observed for PFOS cannot be ruled out (NICNASb).

Public Risk Characterisation

Use in consumer products

Significant direct exposure of the public to the chemicals is not expected. Whilst the public can be exposed to articles treated with the polymers in this group, these are not expected to present significant risks while in polymeric form. Hence, the public risk from these chemicals is not considered to be unreasonable.

Secondary exposure to PFSA via the environment

The primary health risk is expected to arise from secondary, long-term exposure to the degradation products (PFSAs (C5–C7)) from the chemicals in this group.

It is noted that these chemicals could be present in the environment due to historic use, or due to release from articles or the use of other indirect precursor chemicals covered by this assessment. Median levels of PFHxS in Australian blood sera have not significantly changed from 2002. In addition, PFHxS was not detected in a survey of 65 foods and beverages packaged in glass, paper, plastic or cans conducted by Food Standards Australia New Zealand (NICNASb).

The PFSA degradants of the chemicals in this group have been identified as persistent and are known to be, or may be, highly bioaccumulative (NICNASd). Chemicals which are persistent and bioaccumulative remain in the environment and accumulate in biota over an extended period of time, even if new emissions of the chemicals cease. These characteristics can result in very high internal concentrations in exposed organisms, which may cause long-term toxic effects that are not readily identified through standard testing protocols. Chemicals with these hazard characteristics are, therefore, considered to be of concern for the environment (NICNASd).

Occupational Risk Characterisation

Based on the available use information, the chemicals or their products are not manufactured in Australia. Therefore, the non-polymer chemicals are not likely to be used by workers in significant quantities in Australia. Perfluorinated polymers generally do not present significant risks from direct exposure.

Further assessment of the chemicals in this group could be necessary to assess the risk to workers if information becomes available indicating that the non-polymer chemicals in this group are introduced into Australia in significant quantities.

Long-term occupational exposure to low concentrations of PFSA could occur while using these precursors or formulated products containing PFSA as a contaminant.

NICNAS Recommendation

Currently it is recommended that industry seek alternatives to PFSAs related to PFOS and chemicals that can degrade to PFSA, and ultimately aim to phase out their use.

The chemicals in this group have been assessed as having the potential to cause adverse outcomes for the environment (NICNASd). These chemicals are currently listed on the Australian Inventory of Chemical Substances (AICS), and are available to be introduced into Australia without any further assessment by NICNAS. Other chemicals with a reduced potential for adverse outcomes are becoming available but, given the properties of these chemicals, their assessment as new chemicals under the Industrial Chemicals (Notification and Assessment) Act 1989 (the ICNA Act) is still required to fully characterise the human health and environmental risks associated with their use.

It is recommended that NICNAS consult with industry and other stakeholders to consider strategies, including regulatory mechanisms available under the ICNA Act, to encourage the use of safer chemistry.

Advice for industry

Control measures

Control measures to minimise the risk from exposure to the chemicals should be implemented in accordance with the hierarchy of controls. Approaches to minimise risk include substitution, isolation and engineering controls. Measures required to eliminate, or minimise risk arising from storing, handling and using a hazardous chemical depend on the physical form and the manner in which the chemicals are used. Examples of control measures which could minimise the risk include, but are not limited to:

  • using closed systems or isolating operations;  
  • health monitoring for any worker who is at risk of exposure to the chemical[s], if valid techniques are available to monitor the effect on the worker’s health;
  • minimising manual processes and work tasks through automating processes;
  • work procedures that minimise splashes and spills;
  • regularly cleaning equipment and work areas; and
  • using protective equipment that is designed, constructed, and operated to ensure that the worker does not come into contact with the chemicals.

Guidance on managing risks from hazardous chemicals are provided in the Managing risks of hazardous chemicals in the workplace—Code of practice available on the Safe Work Australia website.

Personal protective equipment should not solely be relied upon to control risk and should only be used when all other reasonably practicable control measures do not eliminate or sufficiently minimise risk. Guidance in selecting personal protective equipment can be obtained from Australian, Australian/New Zealand or other approved standards.

Obligations under workplace health and safety legislation

Information in this report should be taken into account to help meet obligations under workplace health and safety legislation as adopted by the relevant state or territory. This includes, but is not limited to:

  • ensuring that hazardous chemicals are correctly classified and labelled;
  • ensuring that (material) safety data sheets ((M)SDS) containing accurate information about the hazards (relating to both health hazards and physicochemical (physical) hazards) of the chemicals are prepared; and
  • managing risks arising from storing, handling and using a hazardous chemical.

Your work health and safety regulator should be contacted for information on the work health and safety laws in your jurisdiction.

Information on how to prepare an (M)SDS and how to label containers of hazardous chemicals are provided in relevant codes of practice such as the Preparation of safety data sheets for hazardous chemicals—Code of practice and Labelling of workplace hazardous chemicals—Code of practice, respectively. These codes of practice are available from the Safe Work Australia website.

A review of the physical hazards of these chemicals has not been undertaken as part of this assessment.


ATSDR (2009) Draft toxicological profile for perfluoroalkyls. Agency For Toxic Substances And Disease Registry. U.S. Department Of Health And Human Services Public Health Service, May 2009.

Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, Jensen AA, Kannan K, Mabury SA and van Leeuwen SP (2011). Perfluoroalkyl and Polyfluoroalkyl Substances in the Environment: Terminology, Classification and Origins. Integrated Environmental Assessment and Management, 7(4), pp 513-541

Calafat AM, Ye X, Silva MJ, Kuklenyik Z and Needham LL (2006). Human exposure assessment toenvironmental chemicals using biomonitoring. International Journal of Andrology 29(1):166-71

ECHA (2015c). Submitted Restrictions under consideration.Perfluorooctanoic acid (PFOA, CAS 335-67-1, EC 206-397-9), including its salts, and any other substance having linear or branched perfluoroheptyl derivatives with the formula C7F15- as a structural element, including its salts except those derivatives with the formula C7F15-X, where X= F, Cl, Br and any other substance having linear or branched perfluorooctyl derivatives with the formula C8F17- as a structural element, including its salts, except those derivatives with the formula C8F17-X, where X= F, Cl, Br or, C8F17-SO2X', C8F17-C(=O)OH or C8F17-CF2-X' (where X'=any group, including salts). Accessed June 2015 at

Fromme H, Schlummer M, Moller A, Gruber L, Wolz G, Ungewiss J, Bohmer S, Dekant W, Mayer R, Liebl Band Twardella D (2007). Exposure of an adult population to perfluorinated substances using duplicate diet portions and biomonitoringdata. Environmental Science& Technology 41(22):7928-7933

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Kato K, Wong LY, Jia LT, Kuklenyik Z and Calafat AM (2011). Trends in exposure to polyfluoroalkylchemicals in the U.S. Population: 1999-2008. Environmental Science& Technology 45(19):8037-8045

National Industrial Chemicals Notification and Assessment Scheme (NICNAS). PFC derivatives and chemicals on which they are based. Available at

NICNASa. Data requirements for notification of new chemical substances containing a perfluorinated carbon chain. Available at

NICNASb. National Industrial Chemical Notification and Assessment Scheme. Tier II human health assessment for Perfluroalkane sulfonates (PFSA) (C5-C7) and their direct precursors. Australian Government Department of Health. Accessed at

NICNASc. National Industrial Chemical Notification and Assessment Scheme. Environment Tier II  Assessment for Indirect Precursors to Perfluorooctanesulfonate (PFOS). Accessed at

NICNASd. National Industrial Chemical Notification and Assessment Scheme. IMAP Environment Tier II Assessment for Direct Precursors to Perfluoroheptanesulfonate (PFHpS), Perfluorohexanesulfonate (PFHxS) and Perfluoropentanesulfonate (PFPeS). Australian Government Department of Health. Available at

OECD (2011). Organisation for Economic Co-operation and Development (OECD) series on Risk Management, No. 24. PFCs: Outcome of the 2009 survey on the production, use and release of PFOS, PFAS, PFOA, PFCA, their related substances and products/mixtures containing these substances.

OECD (2013), OECD/UNEP Global PFC Group, Synthesis paper on per- and polyfluorinated chemicals (PFCs), Environment, Health and Safety, Environment Directorate, OECD. Accessed January 2015 at

Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Accessed March 2015 at

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Substances in Preparations in Nordic Countries (SPIN). Accessed June 2015 at

Sundstorm M, Chang S-C, Noker, P, Gorman G, Hart JA, Ehresman DJ, Bergman A and Butenhoff JL (2012).Comparitive pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys. Reproductive Toxicology 33:441-451

Toms LM, Thompson J, Rotander A, Hobson P, Calafat AM, Kato K, Ye X, Broomhall S, Harden F, MuellerJF (2014). Decline in perfluorooctane sulfonate and perfluorooctanoate serum concentrations in an Australian population from 2002 to 2011. Environ Int. Oct;71:74-80.

United States (US) Personal Care Product Council International Nomenclature of Cosmetic Ingredients (INCI) dictionary. Accessed April 2015 at

US EPA (2002). United States Environmental Protection Agency (US EPA): Perfluoroalkyl Sulfonates; Significant New Use Rule [SNUR], Docket ID: EPA-HQ-OPPT-2002-0043 accessed March 2015 at

US EPA (2007). United States Environmental Protection Agency (US EPA): Perfluoroalkyl Sulfonates; Significant New Use Rule [SNUR], Docket ID: EPA-HQ-OPPT-2005-0015 accessed March 2015 at

US EPA (2015). Significant New Use Rules: Long-Chain Perfluoroalkyl Carboxylate and Perfluoroalkyl Sulfonate Chemical Substances. United States Environmental Protection Agency (US EPA). Accessed February 2015 at!documentDetail;D=EPA-HQ-OPPT-2013-0225-0001

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Last Update 03 July 2015